GLP-1 Receptor Agonists for Obesity Management: A Promising Approach

Obesity has become a critical health issue for people across the world. In the USA, due to obesity, there has been a rapid increase in morbidity and mortality rates in recent years. This indicates a greater threat to individuals' health and lives. 

That's where GLP-1R agonists come to help. It is a promising agent, used in the treatment of people suffering from obesity problems. Let's discuss the role of GLP-1R agonists in obesity management. 

What exactly are GLP-1 Agonists?

GLP-1 receptor agonists, also known as GLP-1R agonists, are a type of medication that mainly helps people with Type 2 diabetes manage their sugar (glucose) levels. While some GLP-1 agonists also assist in treating the obesity problem. 

GLP-1 agonists are injectable medications, where individuals will receive shots in the fatty tissue just under their skin. You can take the injections to areas of your body, including the belly, upper buttocks, outer thighs, and the backs of your arms.

List of FDA-Approved GLP-1 Agonists

The U.S. Food and Drug Administration, also known as the FDA, has approved several medications of GLP-1 Agonists for obesity management. Each one varies a bit in dosage, how long it works, and the intended patient profile. Below are GLP-1 receptor agonist medications which currently available on the market:

1. Semaglutide

Approved by the FDA, Semaglutide is a long-acting GLP-1 agonist used to treat obesity and type 2 diabetes. It works by improving the secretion of insulin, reducing appetite, and slowing digestion. As a result, it lowers blood sugar and promotes weight loss. As a subcutaneous injection, this drug is generally recommended to be taken once a week. In the US, both oral and injectable forms of semaglutide medication are approved to treat T2DM, while only injectable forms are given to manage obesity.

2. Tirzepatide

For targeting both GIP and GLP-1 receptors, Tirzepatide has been developed, which offers dual effects on chronic weight management and blood sugar control. Clinical studies show that people with T2DM and obesity lost significant weight and got better blood sugar control by going through this medication. It is generally given once weekly and delivers better weight-reduction results compared to traditional GLP-1 therapies.

3. Dulaglutide

Dulaglutide is also a long-acting GLP-1 receptor agonist used to manage high blood sugar in type 2 diabetes people. This medication enhances insulin release, slows gastric emptying, and reduces appetite, often leading to weight loss. It reaches peak levels about 48 hours after dosing and is injected one time in a week. According to a study, higher doses of dulaglutide can further reduce body weight, while its long-term efficacy and safety need to be further researched.

4. Liraglutide

Another common GLP-1 receptor agonist is Liraglutide, which is prescribed as a once-daily injection for obesity management. It promotes gradual, sustainable weight loss by increasing feelings of fullness, slowing gastric emptying, and lowering food desires. Getting help with healthy habits, this medication can improve blood sugar levels and support long-term weight loss.

Ende Note

GLP-1 receptor agonists have delivered superior weight loss effects for many individuals. Some of its products are approved by the FDA for chronic weight management for overweight adults. However, this medication is expected to see more clinical trial evidence to showcase its efficacy in obesity treatment. 

National Weight Loss Centers is your go-to destination for obesity management treatment. Our professional team uses FDA-approved GLP-1 weight-loss drugs, which are prescribed by doctors. Book an appointment today to discuss a customized plan.